What Are the Treatment Options for Peyronie’s Disease?

• 1 May 2026
• Mr. Leon Almashan

Last updated on June 15, 2026

Peyronie’s disease treatment ranges from monitoring and mechanical therapies to injections and surgery, depending on the stage of the condition, the degree of curvature and the impact on sexual function.

There is no single treatment pathway that suits every man. Some develop mild curvature that stabilises with little functional difficulty, while others experience worsening bending, pain, shortening or problems during intercourse. Treatment aims vary accordingly. For some men, the priority is managing pain or slowing progression. For others, it is improving function, preserving length or reducing distress around intimacy.

One of the most important distinctions is whether the condition is still changing. During the earlier active phase, curvature and pain may continue to evolve. In the later stable phase, plaque and deformity are usually more settled, and treatment decisions often become clearer.

Some men choose monitoring initially. Others seek earlier intervention because of progression, anxiety or increasing difficulty with sex. A specialist assessment can help clarify which options may be appropriate and whether treatment is worth considering at your current stage.

Observation and Monitoring in Early Stage Peyronie’s Disease

Observation may be appropriate in early cases where symptoms are mild or still evolving. That does not necessarily mean ignoring the condition.

During the active phase, men may notice:

• increasing curvature
• erection pain
• shortening
• indentation or hourglass narrowing
• changes in erectile function

Some urologists prefer to delay more invasive treatment until the disease appears stable, particularly if the deformity is still changing. Monitoring usually involves reviewing curvature progression, pain levels, erectile function and the effect on intercourse over time.

A man with recent onset pain and mild curvature may decide to monitor symptoms initially if sexual function remains largely preserved. Someone experiencing rapid progression or increasing sexual difficulty may prefer earlier discussion about conservative treatment approaches.

This difference in timing is one reason treatment philosophies vary between clinics. Some place greater emphasis on early conservative management rather than waiting for complete stabilisation in every case.

Oral Medications Sometimes Used for Peyronie’s Disease

Some oral medications and supplements have been explored in Peyronie’s disease management, although evidence for meaningful curvature improvement remains mixed.

While some therapies may help pain or inflammation during the active phase, oral treatment alone is unlikely to produce major structural improvement in established curvature.

Most specialists now view oral therapies as supportive rather than transformational treatment. Where deformity is more significant or sexual function is affected, broader treatment planning is usually required.

Injection Treatments That Target Peyronie’s Plaque

Certain injection therapies aim to target plaque tissue within the penis, although suitability depends on plaque characteristics, curvature severity and disease stage.

Collagenase Injections

Collagenase injections are designed to break down selected types of Peyronie’s plaque tissue. They are typically considered in carefully assessed patients and are often combined with penile modelling or traction therapy.

Some men experience improvement in curvature or function, although outcomes vary and treatment does not restore every penis to its previous shape or appearance.

Verapamil Injections

Verapamil injections have historically been explored as another intralesional treatment approach. The proposed aim involves influencing scar-related tissue processes within the plaque, although evidence for consistent curvature improvement remains variable.

Regenerative or Emerging Injection Approaches

Regenerative approaches such as platelet-rich plasma (PRP) or stem-cell-related therapies are sometimes discussed online, although evidence in Peyronie’s disease remains limited and continues to evolve.

Patients should approach highly promotional claims cautiously, particularly where clinics imply guaranteed improvement or universal suitability.

Penile Traction Therapy

Penile traction devices apply gentle mechanical stretching and may form part of a broader Peyronie’s disease management plan in selected cases.

Some clinicians use traction therapy to support:

• curvature management
• penile length preservation
• post-treatment rehabilitation

Devices such as RestoreX are commonly discussed in specialist Peyronie’s settings, although outcomes depend heavily on consistency and patient tolerance.

Traction therapy usually requires regular use over several months, and improvement tends to be gradual rather than immediate. Some men incorporate traction into a daily routine successfully, while others find the time commitment or discomfort difficult to maintain.

For this reason, traction is often discussed alongside other Peyronie’s disease treatment options rather than as a standalone solution.

Shockwave Therapy for Peyronie’s Disease

Shockwave therapy may be used in some Peyronie’s disease treatment plans, particularly where pain is a prominent symptom, although outcomes vary between individuals.

Low-intensity shockwave therapy involves applying acoustic waves to targeted tissue areas. Research has produced mixed findings. Some studies suggest benefit for penile pain during the active phase, while evidence for substantial curvature correction remains less consistent.

This distinction matters because many men search for treatment expecting significant straightening. In practice, outcomes differ considerably depending on:

• disease stage
• plaque characteristics
• baseline curvature
• erectile function

Some clinics also discuss technologies such as EMTT or NanoVi alongside shockwave therapy, although evidence for these approaches in Peyronie’s disease remains limited.

Shockwave therapy is generally best viewed as one component within a broader management strategy rather than a universal solution.

Vacuum Therapy Devices

Vacuum erection devices may sometimes be incorporated into Peyronie’s disease management plans to support penile rehabilitation and erectile function.

These devices create negative pressure around the penis to encourage blood flow and tissue expansion. In Peyronie’s disease care, they are usually discussed as part of combination treatment planning rather than primary structural correction.

Devices such as Soma Erect may be referenced in specialist settings, although protocols and clinical preferences vary. As with traction therapy, consistency and realistic expectations remain important.

Psychosexual Therapy and Counselling

Peyronie’s disease can affect confidence, intimacy and relationships as much as physical function.

Some men begin avoiding sex because of embarrassment, anxiety about progression or concern about how a partner may respond. Others find that repeated difficulty during intercourse gradually affects confidence and relationship dynamics.

Psychosexual support may help with:

• anxiety around intimacy
• communication between partners
• rebuilding confidence
• adapting to treatment-related changes

Even relatively mild curvature can have a significant emotional impact for some patients. A more complete treatment discussion considers both the structural and psychological effects of Peyronie’s disease rather than focusing only on curvature measurements.

Lifestyle Changes That May Support Treatment

Lifestyle changes are unlikely to reverse Peyronie’s disease on their own, but they may support overall vascular and sexual health alongside treatment planning.

Smoking cessation, cardiovascular health, diabetes management and blood pressure control may all be relevant, particularly for men who also experience erectile dysfunction. Lifestyle support is generally best viewed as complementary to appropriate medical assessment rather than an alternative to evidence-based treatment.

When Surgery May Be Recommended

Surgery may be considered in stable, more severe or functionally limiting cases where non-surgical approaches are unlikely to provide sufficient improvement.

Surgical treatment is generally reserved for men whose condition has stabilised and continues to cause significant sexual difficulty.

Factors influencing surgical discussion may include:

• severe curvature
• complex deformity
• erectile dysfunction
• unsuccessful conservative treatment

Plication Procedures and the Nesbit Technique

Plication procedures aim to straighten the penis by shortening the longer side opposite the curve. These approaches are typically considered in men with good erectile function and less complex deformity.

Possible trade-offs include penile shortening, residual curvature and altered sensation.

Grafting Procedures

Grafting techniques may be considered in more complex cases, particularly where preserving length is an important priority. These procedures are more technically involved and may carry greater risks relating to erectile function or healing.

Penile Implants

Penile implants may be discussed in men with Peyronie’s disease and significant erectile dysfunction that has not responded adequately to other treatment.

Implants primarily aim to improve erectile rigidity, although they may also assist with curvature management in selected cases.

Understanding the stages of Peyronie’s disease is important because surgery is usually considered during the stable chronic phase rather than during active progression.

Choosing the Right Treatment for Your Situation

The most appropriate Peyronie’s disease treatment depends on disease stage, plaque characteristics, erectile function, symptom severity and personal priorities.

Two men with apparently similar curvature may still receive very different recommendations. A patient in the active phase with pain but manageable function may prioritise monitoring and conservative management. Someone with stable curvature that significantly affects intercourse may consider traction, injections or surgical discussion differently.

In practice, treatment planning often involves balancing symptom severity, treatment burden, recovery considerations and realistic expectations. The aim is not always perfect straightening. In many cases, the priority is improving function and reducing the impact of the condition on quality of life.

This is one reason assessment matters more than online treatment rankings or exaggerated marketing claims.

A specialist evaluation may include:

• discussion of symptom history
• plaque assessment
• erectile function review
• curvature assessment
• treatment goals and expectations

For some men, reassurance and monitoring may be appropriate. Others may benefit from more active treatment planning or referral for surgical discussion.

If you are concerned about progression, pain, curvature or sexual function, speaking with a specialist from our team at Mans Matters may help clarify which approaches are worth considering. You can also contact us to arrange an assessment to discuss your situation in more detail.