Peyronie’s Disease & Rare Conditions

Lederhosen disease and Dupuytren’s contracture are related fibroproliferative disorders characterised by abnormalities in connective tissue. In Peyronie’s disease, this manifests as fibrous plaque on the penis, leading to curved erections. In Dupuytren’s contracture, the fingers begin to contract as the cords thicken, drawing the fingers towards the palm in a bent position.

In Lederhosen disease, hard nodules begin to develop on the bottom of the feet. It is most commonly seen in middle-aged and elderly individuals and occurs in men approximately 10 times more often than in women. Initially, these hard nodules do not cause pain but can become very painful over time.

The nodules typically form along the plantar fascia of the feet. The plantar fascia is the ligament that runs underneath the foot, just below the skin, connecting the heel to the front of the foot.