Peyronie’s Disease & Vitamin E
Since it has a low cost, and few side effects Vitamin E has been a commonly prescribed oral treatment for Peyronie’s Disease (PD). It has been used in combination with radiotherapy for PD and Shockwave for PD.
Vitamin E is a powerful antioxidant that may help reduce free radical damage and slow the aging process of your cells. It is a fat-soluble nutrient found in many foods and in supplements
In treating PD, the role of Vitamin E is its use as an antioxidant together with its anti-inflammatory proprieties. Additionally, it is thought to reduce collagen deposits within the tunica albuginea.
Early trials of Vitamin E in the treatment of ED reported a reduction in curvature along with pain relief and an improvement in sexual function. In these trials the number of patients treated were quite low so there were concerns about the validity of the treatment.
About 40-years ago the first placebo controlled trial showed limited evidence for Vitamin E over placebo in PD, while more recently it showed no difference in any of the main outcomes considered, including pain relief, when compared to a control group.
The use of Vitamin E has also been tested in combination with other agents with conflicting results.
In conclusion, despite its wide use, the evidence related to the efficacy of Vitamin E in PD is limited and of poor quality.
It should also be noted that elsewhere in medical research there is a lack of proven uses for vitamin E aside from treating vitamin E deficiency, which is a rare condition.
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