A variety of laser devices have been tried for treating the acute phase of Peyronie’s disease non-surgically to use the anti-inflammatory and analgesic biological effects of a low-energy laser.

Low-energy laser therapy has been suggested for 50-years as a safe, and effective treatment for a number of neurological, musculoskeletal and soft tissue conditions.

The first use of a laser as a nonsurgical treatment for Peyronie’s disease was in early 1980’s. Following this many clinical studies with mixed results were published but the last published article regarding the use of laser in the treatment of Peyronie’s disease was more than 10-years ago.

The use of a laser for nonsurgical treatment of Peyronie’s disease is a little difficult to understand since we usually only think about the heating properties of a laser.

But in order to use a laser on the penis a reduction in the heating effects needs to take place. The biological mechanism by which a low-energy laser can stimulate the regenerative processes is unclear, but it has been suggested that it causes an increase in a number of cellular effects including, collagen and cell proliferation as well as inhibiting fibroblastic activity and collagen formation. Whether a low-energy laser can help restore these variables to a more normal level remains unknown.

The historic results of the studies into the use of low-energy laser therapy were contradictory. While patients  experienced pain reduction in the acute phase of the disease, changes in penile curvature and in the reduction of plaque size were shown to be temporary.

What the most effective dose and type of laser to use was also unclear and the treatment  was also not proven in cases of Peyronie’s disease with circular and/or transversal plaques (hourglass deformity, complex or ventral deviations) and when calcified lesions were present (the chronic phase).

With the introduction of shockwave treatment, on-going research of low-energy laser therapy was left behind and neither is it an approved treatment.

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